Macrophage Inflammatory Protein 1 beta (CCL4) Rabbit Polyclonal Antibody

CAT#: TA319702

Rabbit Polyclonal CCL4 Antibody

Product Images

Western blot analysis of CCL4 in rat brain tissue lysate with CCL4 antibody at 1 ug/mL.

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  Immunohistochemistry of CCL4 in rat brain tissue with CCL4 antibody at 2.5 ug/mL.

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  Immunofluorescence of CCL4 in rat brain tissue with CCL4 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal CCL4 antibody was raised against a 15 amino acid peptide near the center of human CCL4.
• Formulation: CCL4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CCL4 Antibody is affinity chromatography purified via peptide column.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 10 kDa
• Gene Name: C-C motif chemokine ligand 4
• Database Link:
  NP_002975
  Entrez Gene 20303 MouseEntrez Gene 116637 RatEntrez Gene 6351 Human
• Background: CCL4 Antibody: CCL4, also known as macrophage inflammatory protein 1-beta (MIP1B), belongs to the intercrine beta (chemokine CC) family. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ; with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells.
• Synonyms: ACT2; AT744.1; G-26; HC21; LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Toll-like receptor signaling pathway