XBP1 Mouse Monoclonal Antibody [Clone ID: 3H1G4]

CAT#: TA319736

Mouse XBP-1 Monoclonal Antibody

Product Images

Western blot analysis of 100 ng of XBP-1 recombinant protein with XBP-1 antibody at 1 ug/mL.

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  Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 2 ug/mL.

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  Immunofluorescence of XBP1 in HepG2 cells with XBP1 antibody at 4 ug/mL.

Specifications

Product Data

• Clone Name: 3H1G4
• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2 ug/mL, IF: 4 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.
• Formulation: XBP-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: X-box binding protein 1
• Database Link:
  NP_001073007
  Entrez Gene 22433 MouseEntrez Gene 289754 RatEntrez Gene 7494 Human
  UniProt ID P17861
• Background: XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
• Synonyms: TREB-5; TREB5; XBP-1; XBP2

Reference Data

• Protein Families: Transcription Factors