XBP1 Mouse Monoclonal Antibody [Clone ID: 9B7E5]

CAT#: TA319737

Mouse XBP-1 Monoclonal Antibody


USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name 9B7E5
Applications IF, WB
Recommended Dilution WB: 1 ug/mL, ICC: 2 ug/mL, IF: 4 ug/mL
Reactivities Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.
Formulation XBP-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name X-box binding protein 1
Background XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
Synonyms TREB-5; TREB5; XBP-1; XBP2
Reference Data
Protein Families Transcription Factors

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.