DYRK2 Rabbit Polyclonal Antibody

CAT#: TA319749

Rabbit Polyclonal DYRK2 Antibody

Product Images

Western blot analysis of DYRK2 in 293 cell lysate with DYRK2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of DYRK2 in 293 cells with DYRK2 antibody at 20 ug/mL.

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  Immunocytochemistry of DYRK2 in 293 cells with DYRK2 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DYRK2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human DYRK2.
• Formulation: DYRK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: DYRK2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: dual specificity tyrosine phosphorylation regulated kinase 2
• Database Link:
  NP_003574
  Entrez Gene 8445 Human
  UniProt ID Q92630
• Background: DYRK2 Antibody: DYRK2 is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family that is thought to be involved in cellular proliferation and apoptosis. Under normal conditions, nuclear but not cytoplasmic DYRK2 is ubiquitinated by MDM2, leading to its constitutive degradation. However, upon exposure to genotoxic stress, ATM phosphorylates DYRK2, leading to its dissociation from MDM2 and its phosphorylation of p53, thereby inducing apoptosis. Recent evidence also suggests that DYRK2 may serve as a scaffold that facilitates assembly of an E3 ubiquitin ligase.
• Synonyms: FLJ21217; FLJ21365

Reference Data

• Protein Families: Druggable Genome, Protein Kinase