CBX4 Rabbit Polyclonal Antibody

CAT#: TA319753

Rabbit Polyclonal CBX4 Antibody

Product Images

Western blot analysis of CBX4 in human brain tissue lysate with CBX4 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of CBX4 in human brain tissue with CBX4 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CBX4 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CBX4.
• Formulation: CBX4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CBX4 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 62 kDa
• Gene Name: chromobox 4
• Database Link:
  NP_003646
  Entrez Gene 12418 MouseEntrez Gene 501403 RatEntrez Gene 8535 Human
  UniProt ID O00257
• Background: CBX4 Antibody: Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
• Synonyms: NBP16; PC2

Reference Data

• Protein Families: Druggable Genome, Transcription Factors