NUMB Rabbit Polyclonal Antibody

CAT#: TA319756

Rabbit Polyclonal NUMB Antibody

Product Images

Western blot analysis of NUMB in mouse lung tissue lysate with NUMB antibody at (A) 0.25 and (B) 0.5 ug/mL.

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  Immunohistochemistry of NUMB in human lung tissue with NUMB antibody at 5 ug/mL.

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  Immunofluorescence of NUMB in human lung tissue with NUMB antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.25 - 0.5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NUMB antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human NUMB.
• Formulation: NUMB Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: NUMB Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NUMB, endocytic adaptor protein
• Database Link:
  NP_001005743
  Entrez Gene 18222 MouseEntrez Gene 29419 RatEntrez Gene 8650 Human
  UniProt ID P49757
• Background: NUMB Antibody: NUMB, the mammalian homolog to the Drosophila asymmetric cell fate determinant NUMB, is thought to share several features molecular mechanisms in mammalian cells, generating asymmetric cell divisions during neurogenesis in vertebrate development as well as in hematopoietic stem cells. NUMB has been shown to inhibit Notch signaling, and is itself regulated by ubiquitinylation by MDM2. NUMB has also been shown to help activate the tumor suppressor p53, suggesting that loss of NUMB in cancerous cells would not only activate the potential oncogene Notch, but diminish the tumor suppressing effect of p53.
• Synonyms: C14orf41; c14_5527; S171

Reference Data

• Protein Pathways: Notch signaling pathway