RIP (RIPK1) Rabbit Polyclonal Antibody

CAT#: TA319759

Rabbit Polyclonal RIP1 Antibody

Product Images

Immunohistochemistry of RIP1 in human placenta tissue with RIP1 antibody at 10 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 - 10 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RIP1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1.
• Formulation: RIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: RIP1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 74 kDa
• Gene Name: receptor interacting serine/threonine kinase 1
• Database Link:
  NP_003795
  Entrez Gene 8737 Human
  UniProt ID Q13546
• Background: RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
• Synonyms: RIP; RIP-1; RIP1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway