RIP (RIPK1) Rabbit Polyclonal Antibody

CAT#: TA319759

Rabbit Polyclonal RIP1 Antibody


USD 430.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Applications IHC
Recommended Dilution IHC: 5 - 10 ug/mL
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen RIP1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1.
Formulation RIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification RIP1 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 74 kDa
Gene Name receptor interacting serine/threonine kinase 1
Background RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
Synonyms RIP; RIP-1; RIP1
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Apoptosis, Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.