TIF1 alpha (TRIM24) Rabbit Polyclonal Antibody

CAT#: TA319761

Rabbit Polyclonal TRIM24 Antibody

Product Images

Western blot analysis of TRIM24 in EL4 cell lysate with TRIM24 antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunofluorescence of TRIM24 in EL4 cells with TRIM24 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRIM24 antibody was raised against a 19 amino acid peptide near the center of human TRIM24.
• Formulation: TRIM24 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TRIM24 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 112 kDa
• Gene Name: tripartite motif containing 24
• Database Link:
  NP_003843
  Entrez Gene 21848 MouseEntrez Gene 500084 RatEntrez Gene 8805 Human
  UniProt ID O15164
• Background: TRIM24 Antibody: TRIM24 (TIF1), a member of the tripartite motif (TRIM) family, plays a role in the regulation of cell proliferation and apoptosis. TRIM24 localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The TRIM motif includes three zinc-binding domains (RING, B-box type 1 and B-box type 2) and a coiled-coil region. TIF1 mediates transcriptional events by interactions with the AF2 region of several nuclear receptors, such as the estrogen, retinoic acid and vitamin D3 receptors. Defects in TRIM24 are a cause of thyroid papillary carcinoma (TPC).
• Synonyms: hTIF1; PTC6; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Transcription Factors