PIWIL1 Rabbit Polyclonal Antibody

CAT#: TA319776

Rabbit Polyclonal PIWI-L1 Antibody

Product Images

Western blot analysis of PIWI-L1 in HepG2 cell lysate with PIWI-L1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of PIWI-L1 in rat liver tissue with PIWI-L1 antibody at 10 ug/mL.

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  Immunofluorescence of PIWI-L1 in rat liver tissue with PIWI-L1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: PIWI-L1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human PIWI-L1.
• Formulation: PIWI-L1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: PIWI-L1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: piwi like RNA-mediated gene silencing 1
• Database Link:
  NP_001177900
  Entrez Gene 57749 MouseEntrez Gene 363912 RatEntrez Gene 9271 Human
  UniProt ID Q96J94
• Background: PIWI-L1 Antibody: PIWI-L1 is a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that are crucial for the biogenesis and function of small non-coding RNAs and play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. PIWI-L1 is thought to play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells as removing PIWI-L1 protein from single germline stem cells significantly decreases the rate of their division. Recent studies have shown that overexpression of PIWI-L1 (as well as other PIWI-like proteins) are potential biomarkers for colon and other cancers.
• Synonyms: CT80.1; HIWI; MIWI; PIWI

Reference Data

• Protein Pathways: Dorso-ventral axis formation