Klotho (KL) Rabbit Polyclonal Antibody

CAT#: TA319778

Rabbit Polyclonal KLOTHO Antibody

Product Images

Western blot analysis of KLOTHO in rat heart tissue lysate with KLOTHO antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of KLOTHO in mouse heart tissue with KLOTHO antibody at 2.5 ug/mL.

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  Immunofluorescence of KLOTHO in mouse heart tissue with KLOTHO antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KLOTHO antibody was raised against a 16 amino acid synthetic peptide near the center of human KLOTHO.
• Formulation: KLOTHO Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: KLOTHO Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: klotho
• Database Link:
  NP_004786
  Entrez Gene 16591 MouseEntrez Gene 83504 RatEntrez Gene 9365 Human
  UniProt ID Q9UEF7
• Background: KLOTHO Antibody: KLOTHO is the systemic anti-aging hormone within the glycosidase1 superfamily. It encodes a type I membrane protein that is abundant in the kidney and brain. In mice, a deficiency in KLOTHO expression leads to various systemic phenotypes resembling human aging such as arteriosclerosis, osteoporosis, and skin atrophy together with growth retardation, short life-span and infertility. Transgenic mice overexpressing KLOTHO have an extended life span by inhibiting insulin/IGF1 signaling. KLOTHO is involved in the regulation of calcium/phosphorus homeostasis by inhibiting the synthesis of active vitamin D and identified as a potential tumor suppressor.
• Synonyms: klotho; OTTHUMP00000018796

Reference Data

• Protein Families: Secreted Protein, Transmembrane