Serine Palmitoyltransferase (SPTLC2) Rabbit Polyclonal Antibody

CAT#: TA319780

Rabbit Polyclonal SPT2 Antibody


USD 430.00

2 Weeks*

Size
    • 100 ug

Product Images

Other products for "SPTLC2"

Specifications

Product Data
Applications IF, WB
Recommended Dilution WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen SPT2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPT2.
Formulation SPT2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification SPT2 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name serine palmitoyltransferase long chain base subunit 2
Background SPT2 Antibody: Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
Synonyms hLCB2a; HSN1C; LCB2; LCB2A; NSAN1C; SPT2
Reference Data
Protein Pathways Metabolic pathways, Sphingolipid metabolism

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.