EI24 Rabbit Polyclonal Antibody

CAT#: TA319782

Rabbit Polyclonal EI24 Antibody

Product Images

Western blot analysis of EI24 in rat liver tissue lysate with EI24 antibody at (A) 1 and (B) 2 ug/mL.

• 

  Immunohistochemistry of EI24 in rat liver tissue with EI24 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24.
• Formulation: EI24 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: EI24 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: EI24, autophagy associated transmembrane protein
• Database Link:
  NP_004870
  Entrez Gene 13663 MouseEntrez Gene 300514 RatEntrez Gene 9538 Human
  UniProt ID O14681
• Background: EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer.
• Synonyms: EPG4; PIG8; TP53I8

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: p53 signaling pathway