RIM2 (RIMS2) Rabbit Polyclonal Antibody

CAT#: TA319784

Rabbit Polyclonal RIM2 Antibody

Product Images

Immunohistochemistry of RIM2 in adrenal gland tissue with RIM2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IHC
• Recommended Dilution: IHC: 5 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: RIM2 antibody was raised against a 16 amino acid peptide near the carboxy terminusof human RIM2.
• Formulation: RIM2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: RIM2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 148 kDa
• Gene Name: regulating synaptic membrane exocytosis 2
• Database Link:
  NP_055492
  Entrez Gene 9699 Human
  UniProt ID Q9UQ26
• Background: RIM2 Antibody: Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM1 and RIM2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM1, RIM2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
• Synonyms: OBOE; RAB3IP3; RIM2