ULK2 Rabbit Polyclonal Antibody

CAT#: TA319785

Rabbit Polyclonal ULK2 Antibody

Product Images

Western blot analysis of ULK2 in human brain tissue lysate with ULK2 antibody at 1 ug/mL.

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  Immunohistochemistry of ULK2 in human brain tissue with ULK2 antibody at 2.5 ug/mL.

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  Immunofluorescence of ULK2 in human brain tissue with ULK2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ULK2 antibody was raised against a 17 amino acid peptide near the center of human ULK2 .
• Formulation: ULK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ULK2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 105, 114 kDa; Observed: 100 kDa
• Gene Name: unc-51 like autophagy activating kinase 2
• Database Link:
  NP_001136082
  Entrez Gene 9706 Human
  UniProt ID Q8IYT8
• Background: ULK2 Antibody: ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
• Synonyms: ATG1B; Unc51.2

Reference Data

• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: mTOR signaling pathway, Regulation of autophagy