SPCA2 (ATP2C2) Rabbit Polyclonal Antibody

CAT#: TA319799

Rabbit Polyclonal ATP2C2 Antibody

Product Images

Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide

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  Immunofluorescence of ATP2C2 in 3T3 cells with ATP2C2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ATP2C2 antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP2C2.
• Formulation: ATP2C2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ATP2C2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATPase secretory pathway Ca2+ transporting 2
• Database Link:
  NP_055676
  Entrez Gene 69047 MouseEntrez Gene 9914 Human
  UniProt ID O75185
• Background: ATP2C2 Antibody: ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
• Synonyms: SPCA2

Reference Data

• Protein Families: Druggable Genome, Transmembrane