APC2 Rabbit Polyclonal Antibody

CAT#: TA319810

Rabbit Polyclonal APC2 Antibody

Product Images

Western blot analysis of APC2 in HeLa cell lysate with APC2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of APC2 in HeLa cells with APC2 antibody at 20 ug/mL.

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  Immunocytochemistry of APC2 in HeLa cells with APC2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APC2 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC2.
• Formulation: APC2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: APC2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: adenomatosis polyposis coli 2
• Database Link:
  NP_005874
  Entrez Gene 23805 MouseEntrez Gene 10297 Human
  UniProt ID O95996
• Background: APC2 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
• Synonyms: APCL

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Pathways in cancer, Regulation of actin cytoskeleton, Wnt signaling pathway