Epac1 (RAPGEF3) Rabbit Polyclonal Antibody

CAT#: TA319816

Rabbit Polyclonal EPAC1 Antibody

Product Images

Western blot analysis of EPAC1 in rat skeletal muscle tissue lysate with EPAC1 antibody at 1 ug/mL.

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  Immunohistochemistry of EPAC1 in rat brain tissue with EPAC1 antibody at 2.5 ug/mL.

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  Immunofluorescence of EPAC1 in rat brain tissue with EPAC1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: EPAC1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EPAC1.
• Formulation: EPAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: EPAC1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: Rap guanine nucleotide exchange factor 3
• Database Link:
  NP_001092001
  Entrez Gene 59326 RatEntrez Gene 223864 MouseEntrez Gene 10411 Human
  UniProt ID O95398
• Background: EPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
• Synonyms: bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275

Reference Data

• Protein Pathways: Leukocyte transendothelial migration, Long-term potentiation