PRMT4 (CARM1) Rabbit Polyclonal Antibody

CAT#: TA319822

Rabbit Polyclonal CARM1 Antibody

Product Images

Western blot analysis of CARM1 in Jurkat cell lysate with CARM1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

• 

  Immunofluorescence of CARM1 in Jurkat cells with CARM1 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal CARM1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CARM1.
• Formulation: CARM1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CARM1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 67 kDa
• Gene Name: coactivator associated arginine methyltransferase 1
• Database Link:
  NP_954592
  Entrez Gene 59035 MouseEntrez Gene 363026 RatEntrez Gene 10498 Human
  UniProt ID Q86X55
• Background: CARM1 Antibody: Protein arginine N-methyltransferases, such as CARM1, catalyze the transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine. Protein arginine methylation has been implicated in signal transduction, metabolism of nascent pre-RNA, and transcriptional activation. CARM1 functions as a transcriptional co-activator for various nuclear receptors and NF-κB. It has also been shown to methylate histone H3 arginines, inhibiting the binding of corepressors and protecting chromatin from deacetylation, thereby facilitating transcription.
• Synonyms: PRMT4

Reference Data

• Protein Families: Druggable Genome, Transcription Factors