MAN1 (LEMD3) Rabbit Polyclonal Antibody

CAT#: TA319866

Rabbit Polyclonal LEMD3 Antibody

Product Images

Western blot analysis of LEMD3 in human colon tissue lysate with LEMD3 antibody at 1 ug/mL.

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  Immunohistochemistry of LEMD3 in human colon tissue with LEMD3 antibody at 2.5 ug/mL.

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  Immunofluorescence of LEMD3 in human colon tissue with LEMD3 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: LEMD3 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LEMD3.
• Formulation: LEMD3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: LEMD3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: LEM domain containing 3
• Database Link:
  NP_001161086
  Entrez Gene 380664 MouseEntrez Gene 23592 Human
  UniProt ID Q9Y2U8
• Background: LEMD3 Antibody: LEMD3 (LEM domain-containing 3) is a lem-domain containing protein, also known as MAN1, whose loss of function results in disorders characterized by osteopoikilosis, Buschke-Ollendorff syndrome, and melorheostosis. LEMD3 is an inner nuclear membrane protein that interacts with BMP and activin-TGF-beta receptor-activated Smads and antagonizes TGF-beta signaling in human cells.
• Synonyms: MAN1

Reference Data

• Protein Families: Transmembrane