ZNF521 Rabbit Polyclonal Antibody

CAT#: TA319876

Rabbit Polyclonal ZNF521 Antibody

Product Images

Western blot analysis of ZNF521 in HeLa cell lysate with ZNF521 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of ZNF521 in HeLa cells with ZNF521 antibody at 20 ug/mL.

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  Immunocytochemistry of ZNF521 in HeLa cells with ZNF521 antibody at 2.5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ZNF521 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ZNF521.
• Formulation: ZNF521 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ZNF521 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: zinc finger protein 521
• Database Link:
  NP_056276
  Entrez Gene 25925 Human
  UniProt ID Q96K83
• Background: ZNF521 Antibody: The zinc finger protein 521 (ZNF521) is a transcription factor containing an N-terminal transcriptional repressor motif and 30 zinc finger domains. It plays a role in both erythroid cell and osteoblast differentiation during development, inhibiting the activities of early B-cell factor 1 (EBF1) in erythroid cells and Runx2 in osteoblast precursors. ZFP521 binds to both Runx2 and histone deacetylase 3 (HDAC3), promotes their association and antagonizes Runx2 transcriptional activity in a HDAC3-dependent manner, thereby regulating osteoblast differentiation, skeletal development, and bone homeostasis.
• Synonyms: EHZF; Evi3