ATP2C1 Rabbit Polyclonal Antibody

CAT#: TA319887

Rabbit Polyclonal ATP2C1 Antibody

Product Images

Western blot analysis of ATP2C1 in mouse brain tissue lysate with ATP2C1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

• 

  Immunohistochemistry of ATP2C1 in mouse brain tissue with ATP2C1 antibody at 5 ug/mL.

• 

  Immunofluorescence of ATP2C1 in mouse brain tissue with ATP2C1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: ATP2C1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ATP2C1.
• Formulation: ATP2C1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ATP2C1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATPase secretory pathway Ca2+ transporting 1
• Database Link:
  NP_055197
  Entrez Gene 235574 MouseEntrez Gene 27032 Human
  UniProt ID P98194
• Background: ATP2C1 Antibody: ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
• Synonyms: ATP2C1A; BCPM; HHD; hSPCA1; PMR1; SPCA1

Reference Data

• Protein Families: Druggable Genome, Transmembrane