DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: 8B6]

CAT#: TA319910

Mouse DC-SIGN Monoclonal Antibody

Product Images

Western blot detection of DC-SIGN fusion protein in human uterus tissue lysate at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of DC-SIGN in lymph node tissue with DC-SIGN antibody at 10 ug/mL.

Specifications

Product Data

• Clone Name: 8B6
• Applications: IHC, WB
• Recommended Dilution: WB: 1 - 2 mg/mL, ICC: 5 - 10 mg/mL
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Immunogen: A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
• Formulation: DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD209 molecule
• Database Link:
  NP_001138365
  Entrez Gene 30835 Human
  UniProt ID Q9NNX6
• Background: DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
• Synonyms: CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1

Reference Data

• Protein Families: Druggable Genome