MECR Rabbit Polyclonal Antibody

CAT#: TA319915

Rabbit Polyclonal MECR Antibody

Product Images

Western blot analysis of MECR in human brain tissue lysate with MECR antibody at (A) 1 and (B) 2 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal MECR antibody was raised against a 15 amino acid peptide near the carboxy terminus of human MECR.
• Formulation: MECR Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: MECR Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 41 kDa
• Gene Name: mitochondrial trans-2-enoyl-CoA reductase
• Database Link:
  NP_057095
  Entrez Gene 26922 MouseEntrez Gene 29470 RatEntrez Gene 51102 Human
  UniProt ID Q9BV79
• Background: MECR Antibody: The mitochondrial trans-2-enoyl-CoA reductase (MECR), was initially identified as nuclear receptor-binding factor 1 (NRBF1), which can interact with a multitude of nuclear hormone receptors in the presence of the respective ligands. MECR has been shown to be part of the mitochondrial fatty acid synthesis (FAS II) system and to catalyze the NAPDH-dependent reduction of 2-enoyl thioesters, generating saturated acyl-groups. Overexpression of this gene in transgenic mice can lead to cardiac abnormalities, suggesting that inappropriate expression of genes of FAS II can result in the development of hereditary cardiomyopathy.
• Synonyms: CGI-63; FASN2B; NRBF1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Fatty acid elongation in mitochondria, Metabolic pathways