Apc7 (ANAPC7) Rabbit Polyclonal Antibody

CAT#: TA319926

Rabbit Polyclonal APC7 Antibody

Product Images

Western blot analysis of APC7 in rat kidney tissue lysate with APC7 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of APC7 in rat kidney tissue with APC7 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: APC7 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human APC7.
• Formulation: APC7 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: APC7 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: anaphase promoting complex subunit 7
• Database Link:
  NP_057322
  Entrez Gene 56317 MouseEntrez Gene 304490 RatEntrez Gene 51434 Human
  UniProt ID Q9UJX3
• Background: APC7 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.
• Synonyms: APC7

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation, Ubiquitin mediated proteolysis