SIRT6 Chicken Polyclonal Antibody

CAT#: TA319931

Chicken Polyclonal SIRT6 Antibody

Product Images

Western blot analysis of SIRT6 in HeLa cell lysate with SIRT6 antibody at (A) 0.5 and (B) 1 ug/mL.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 0.5 - 1 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: SIRT6 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human SIRT6.
• Formulation: SIRT6 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: SIRT6 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: sirtuin 6
• Database Link:
  NP_001180214
  Entrez Gene 50721 MouseEntrez Gene 299638 RatEntrez Gene 51548 Human
  UniProt ID Q8N6T7
• Background: SIRT6 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT6 is a histone H3 lysine 9 deacetylase and is thought to stabilize the DNA-dependent protein kinase at double-stranded DNA breaks and may have a role in the process of mammalian aging.
• Synonyms: SIR2L6

Reference Data

• Protein Families: Druggable Genome, Transcription Factors