TIF1 gamma (TRIM33) Rabbit Polyclonal Antibody

CAT#: TA319933

Rabbit Polyclonal TRIM33 Antibody

Product Images

Western blot analysis of TRIM33 in human liver tissue lysate with TRIM33 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunohistochemistry of TRIM33 in human liver tissue with TRIM33 antibody at 2.5 ug/mL.

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  Immunofluorescence of TRIM33 in human liver tissue with TRIM33 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TRIM33 antibody was raised against an 18 amino acid peptide near the center of human TRIM33.
• Formulation: TRIM33 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: TRIM33 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 70, 124 kDa; Observed: 70 kDa
• Gene Name: tripartite motif containing 33
• Database Link:
  NP_056990
  Entrez Gene 94093 MouseEntrez Gene 365894 RatEntrez Gene 51592 Human
  UniProt ID Q9UPN9
• Background: TRIM33 Antibody: TRIM24 (TIF1alpha), TRIM28 (TIF1beta), and TRIM33 (TIF1gamma) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors (1-2). The structure of TRIM33 is similar to TRIM24 and TRIM28, exhibiting multiple domains (RING finger, coiled coil, B boxes, PHD/TTC, and bromodomain) (3). TRIM33 functions in cell differentiation and development, playing a role in differentiation of hematopoietic cells (3). It interacts with the Smad2/3 transcription factor in hematopoietic, mesenchymal, and epithelial cell types to mediate different transcriptional effects in response to TGF-beta (4). It acts as an E3 ubiquitin-protein ligase and promotes SMAD4 ubiquitination (5).
• Synonyms: ECTO; PTC7; RFG7; TF1G; TIF1G; TIF1GAMMA; TIFGAMMA

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transcription Factors