Dectin 1 (CLEC7A) Rabbit Polyclonal Antibody

CAT#: TA320003

Rabbit Polyclonal CLEC7A Antibody

Product Images

Western blot analysis of CLEC7A in rat spleen tissue lysate with CLEC7A antibody at (A) 1 and (B) 2 ug/.

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  Immunohistochemistry of CLEC7A in human spleen tissue with CLEC7A antibody at 5 ug/mL.

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  Immunofluorescence of CLEC7A in human spleen tissue withCLEC7A antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 5 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CLEC7A antibody was raised against a 17 amino acid synthetic peptide near the center of human CLEC7A.
• Formulation: CLEC7A Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: CLEC7A Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: C-type lectin domain family 7 member A
• Database Link:
  NP_072092
  Entrez Gene 56644 MouseEntrez Gene 502902 RatEntrez Gene 64581 Human
  UniProt ID Q9BXN2
• Background: CLEC7A Antibody: CLEC7A, also known as dectin-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily and is predominantly expressed on myeloid cells. It is a small glycoprotein type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif (ITAM). CLEC7A functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Upon fungal exposure, CLEC7A activates Syk tyrosine kinase, triggering a massive oxidative burst through the formation of reactive oxygen species.
• Synonyms: BGR; CANDF4; CD369; CLECSF12; DECTIN1; SCARE2

Reference Data

• Protein Families: Druggable Genome, Transmembrane