VKORC1 Rabbit Polyclonal Antibody

CAT#: TA320006

Rabbit Polyclonal VKORC1 Antibody

Product Images

Western blot analysis of VKORC1 in A549 cell lysate with VKORC1 antibody at 1 ug/mL.

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  Immunohistochemistry of VKORC1 in human lung tissue with VKORC1 antibody at 2.5 ug/mL.

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  Immunofluorescence of VKORC1 in human lung tissue with VKORC1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1.
• Formulation: VKORC1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: VKORC1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: vitamin K epoxide reductase complex subunit 1
• Database Link:
  NP_076869
  Entrez Gene 27973 MouseEntrez Gene 79001 Human
  UniProt ID Q9BQB6
• Background: VKORC1 Antibody: Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.
• Synonyms: EDTP308; MST134; MST576; VKCFD2; VKOR

Reference Data

• Protein Families: Transmembrane