VKORC1 Rabbit Polyclonal Antibody
Other products for "VKORC1"
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommended Dilution | WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 5 ug/mL |
Reactivities | Human, Mouse |
Host | Rabbit |
Isotype | IgG |
Clonality | Polyclonal |
Immunogen | VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1. |
Formulation | VKORC1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | VKORC1 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | vitamin K epoxide reductase complex subunit 1 |
Database Link | |
Background | VKORC1 Antibody: Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. |
Synonyms | EDTP308; MST134; MST576; VKCFD2; VKOR |
Reference Data | |
Protein Families | Transmembrane |
Documents
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