KREMEN2 Rabbit Polyclonal Antibody

CAT#: TA320011

Rabbit Polyclonal KREMEN2 Antibody

Product Images

Western blot analysis of KREMEN2 in HeLa cell lysate with KREMEN2 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunocytochemistry of KREMEN2 in HeLa cells with KREMEN2 antibody at 5 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .
• Formulation: KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Purification: KREMEN2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 51 kDa; Observed: 54 kDa
• Gene Name: kringle containing transmembrane protein 2
• Database Link:
  NP_663323
  Entrez Gene 73016 MouseEntrez Gene 79412 Human
  UniProt ID Q8NCW0
• Background: KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
• Synonyms: kringle-containing transmembrane protein 2; kringle containing transmembrane protein 2; KRM2; MGC10791; MGC16709

Reference Data

• Protein Families: Druggable Genome, Transmembrane