CXXC4 Rabbit Polyclonal Antibody

CAT#: TA320030

Rabbit Polyclonal CXXC4 Antibody

Product Images

Western blot analysis of CXXC4 in human brain tissue lysate with CXXC4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunohistochemistry of CXXC4 in human brain tissue with CXXC4 antibody at 10 ug/mL.

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  Immunofluorescence of CXXC4 in human brain tissue with CXXC4 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CXXC4 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CXXC4.
• Formulation: CXXC4 Antibody is supplied in PBS containing 0.02% sodium azide.
• Purification: CXXC4 Antibody is affinity chromatography purified via peptide column.
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CXXC finger protein 4
• Database Link:
  NP_079488
  Entrez Gene 83824 RatEntrez Gene 319478 MouseEntrez Gene 80319 Human
• Background: CXXC4 Antibody: CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4's interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
• Synonyms: IDAX

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Wnt signaling pathway