KREMEN1 Rabbit Polyclonal Antibody

CAT#: TA320040

Rabbit Polyclonal KREMEN1 Antibody

Product Images

Western blot analysis of KREMEN1 in rat small intestine tissue lysate with KREMEN1 antibody at (A) 0.125 and (B) 0.25 ug/mL

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  Immunohistochemistry of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 5 ug/mL.

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  Immunofluorescence of KREMEN1 in human small intestine tissue with KREMEN1 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 0.125 - 0.25 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Rabbit polyclonal KREMEN1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KREMEN1.
• Formulation: KREMEN1 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: KREMEN1 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 54 kDa
• Gene Name: kringle containing transmembrane protein 1
• Database Link:
  NP_001034659
  Entrez Gene 84035 MouseEntrez Gene 114107 RatEntrez Gene 83999 Human
  UniProt ID Q96MU8
• Background: KREMEN1 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) coreceptor. KREMEN1 is a receptor for the Dickkopf protein which blocks Wnt/beta catenin signaling. It is necessary to ensure normal spatial and temporal patterns of Wnt activity during developmental processes.
• Synonyms: KREMEN; KRM1

Reference Data

• Protein Families: Druggable Genome, Transmembrane