ZGPAT Chicken Polyclonal Antibody

CAT#: TA320054

Chicken Polyclonal ZGPAT Antibody

Product Images

Western blot analysis of ZGPAT in SK-N-SH cell lysate with ZGPAT antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.

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  Immunofluorescence of ZGPAT in human brain cells with ZGPAT antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Chicken
• Isotype: IgY
• Clonality: Polyclonal
• Immunogen: ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT.
• Formulation: ZGPAT Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: ZGPAT Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: zinc finger CCCH-type and G-patch domain containing
• Database Link:
  NP_852149
  Entrez Gene 84619 Human
  UniProt ID Q8N5A5
• Background: ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.
• Synonyms: CCCH-type with G patch domain; GPATC6; GPATCH6; KIAA1847; MGC44880; OTTHUMP00000031593; OTTHUMP00000031594; OTTHUMP00000031596; RP4-583P15.3; ZC3H9; ZC3HDC9; zinc finger