IL33 Mouse Monoclonal Antibody [Clone ID: 12H6D12]

CAT#: TA320070

Mouse IL-33 Monoclonal Antibody

Product Images

Western blot analysis of IL-33 using 125ng of recombinant IL-33 with IL-33 antibody at 1 ug/mL.

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  Immunohistochemistry of IL-33 in human lymph node tissue with IL-33 antibody at 5 ug/mL.

Specifications

Product Data

• Clone Name: 12H6D12
• Applications: IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein.
• Formulation: IL-33 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: IL-33 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 33
• Database Link:
  NP_001186569
  Entrez Gene 77125 MouseEntrez Gene 90865 Human
  UniProt ID O95760
• Background: IL-33 Monoclonal Antibody: Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1αβ, IL-1Ra and IL-18. Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP). Receptor binding of IL-33 activates NF-κB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
• Synonyms: C9orf26; DVS27; IL1F11; NF-HEV; NFEHEV

Reference Data

• Protein Families: Secreted Protein
• Protein Pathways: Cytosolic DNA-sensing pathway