NALP12 (NLRP12) Rabbit Polyclonal Antibody

CAT#: TA320073

Rabbit Polyclonal NALP12 Antibody

Product Images

Western blot analysis of NALP12 in human brain tissue lysate with NALP12 antibody at 1 ug/mL.

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  Immunohistochemistry of NALP12 in human brain tissue with NALP12 antibody at 5 ug/mL.

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  Immunofluorescence of NALP12 in human brain tissue with NALP12 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NALP12 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP12.
• Formulation: NALP12 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: NALP12 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NLR family, pyrin domain containing 12
• Database Link:
  NP_150639
  Entrez Gene 292541 RatEntrez Gene 378425 MouseEntrez Gene 91662 Human
  UniProt ID P59046
• Background: NALP12 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP12, also known as Monarch-1, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. NALP12 is thought to act as an attenuating factor of inflammation by suppressing inflammatory responses such as NF-κB activation by TLR-signaling molecules MyD88, IRAK-1, TRAF6 and RIPK1 in activated monocytes. Recent evidence suggests that mutations in NALP12 result in hereditary periodic fever syndromes.
• Synonyms: CLR19.3; FCAS2; NALP12; PAN6; PYPAF7; RNO; RNO2