NLRC3 Rabbit Polyclonal Antibody

CAT#: TA320135

Rabbit Polyclonal NOD3 Antibody

Product Images

Western blot analysis of NOD3 in 3T3 cell lysate with NOD3 antibody at (A) 1 and (B) 2 ug/mL.

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  Immunofluorescence of NOD3 in Jurkat cells with NOD3 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IF: 20 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3.
• Formulation: NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: NOD3 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: NLR family, CARD domain containing 3
• Database Link:
  NP_849172
  Entrez Gene 268857 MouseEntrez Gene 287070 RatEntrez Gene 197358 Human
  UniProt ID Q7RTR2
• Background: NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.
• Synonyms: CLR16.2; NOD3

Reference Data

• Protein Families: Druggable Genome