TORC2 (CRTC2) Rabbit Polyclonal Antibody

CAT#: TA320138

Rabbit Polyclonal CRTC2 Antibody

Product Images

Western blot analysis of CRTC2 in human small intestine tissue lysate with CRTC2 antibody at (A) 0.5 and (B) 1 ug/mL.

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  Immunohistochemistry of CRTC2 in human small intestine tissue with CRTC2 antibody at 2.5 ug/mL.

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  Immunofluorescence of CRTC2 in human small intestine tissue with CRTC2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CRTC2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human CRTC2.
• Formulation: CRTC2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CRTC2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 67, 76 kDa; Observed: 70 kDa
• Gene Name: CREB regulated transcription coactivator 2
• Database Link:
  NP_859066
  Entrez Gene 74343 MouseEntrez Gene 310615 RatEntrez Gene 200186 Human
  UniProt ID Q53ET0
• Background: CRTC2 Antibody: CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB)) 2 and the related protein CRTC1 are potent CREB coactivators that are exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Studies suggest that their phosphorylation and nuclear/cytoplasmic shuttling play an important role in the regulation of gluconeogenesis by cAMP. CRTC2 is present in both B and T-lymphocytes and abundantly expressed in the thymus. Its activity is important in regulating the expression of genes involved in cellular energy metabolism while CRTC1 is essential for energy balance and fertility.
• Synonyms: TORC-2; TORC2