CISD2 Rabbit Polyclonal Antibody

CAT#: TA320192

Rabbit Polyclonal CISD2 Antibody


USD 430.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Applications IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL
Reactivities Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.
Formulation CISD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification CISD2 Antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size Predicted: 15 kDa; Observed: 15 kDa
Gene Name CDGSH iron sulfur domain 2
Background CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
Synonyms ERIS; Miner1; NAF-1; WFS2; ZCD2
Reference Data
Protein Families Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.