CISD2 Rabbit Polyclonal Antibody

CAT#: TA320192

Rabbit Polyclonal CISD2 Antibody

Product Images

Western blot analysis of CISD2 in rat brain tissue lysate with CISD2 antibody at (A) 1 and (B) 2 ??g/m

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  Immunohistochemistry of CISD2 in rat brain tissue with CISD2 antibody at 2.5 ug/mL.

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  Immunofluorescence of CISD2 in rat brain tissue with CISD2 antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: CISD2 antibody was raised against a 15 amino acid peptide near the center of human CISD2.
• Formulation: CISD2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: CISD2 Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 15 kDa; Observed: 15 kDa
• Gene Name: CDGSH iron sulfur domain 2
• Database Link:
  NP_001008389
  Entrez Gene 67006 MouseEntrez Gene 295457 RatEntrez Gene 493856 Human
  UniProt ID Q8N5K1
• Background: CISD2 Antibody: Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.
• Synonyms: ERIS; Miner1; NAF-1; WFS2; ZCD2

Reference Data

• Protein Families: Transmembrane