CD1 (CD1D) Mouse Monoclonal Antibody [Clone ID: 51.1]

CAT#: TA320245

Mouse Anti-Human CD1d Purified (100 ug)

Product Images

Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG2b K Isotype Control Purified (open histogram) or Anti-Human CD1d Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE. Cells in the lymphocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: 51.1
• Applications: FC
• Recommended Dilution: Flow, IHC, IP
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD1d molecule
• Database Link:
  NP_001757
  Entrez Gene 912 Human
  UniProt ID P15813
• Background: The monoclonal antibody 51.1 reacts with human CD1d, a member of the CD1 family with similarity to the non-polymorphic MHC Class I-like molecules. CD1d is a highly conserved single transmembrane receptor of the Immunoglobulin Superfamily. CD1d can associate with beta-microglobulin another feature showing similarity to MHC class I molecules, but can also exist as a nonglycosylated protein not in association with beta microglobulin. This suggests different control mechanisms for presenting glycolipid containing molecules to CD1d reactive NKT cells. Expression of CD1d is found on B cells of the periphery, in resting monocytes and cortical thymocytes. On intestinal epithelial cells (IEC) expression is polarized. Expression can also be found at low levels intracellularly in hepatocytes. In HCV (hepatitis C virus) livers, CD1d is highly expressed compared to normal controls.
• Synonyms: CD1A; R3; R3G1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Hematopoietic cell lineage