CD27 Hamster Monoclonal Antibody [Clone ID: LG.3A10]

CAT#: TA320251

Hamster Anti-Human/Mouse CD27 Purified (100 ug)

Product Images

Staining of BALB/c splenocytes with Anti-Human/Mouse CD45R (B220) FITC and 0.125 ug Anti-CD27 Purified followed by Anti-Armenian Hamster IgG PE. Total viable cells were analyzed.

Specifications

Product Data

• Clone Name: LG.3A10
• Applications: FC
• Recommended Dilution: Flow, IHC, IP
• Reactivities: Human, Mouse
• Host: Hamster
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD27 molecule
• Database Link:
  NP_001233
  Entrez Gene 21940 MouseEntrez Gene 939 Human
  UniProt ID P26842
• Background: The LG.3A10 monoclonal antibody reacts with mouse CD27, a lymphocyte-specific member of the TNFR superfamily. CD27 is expressed by virtually all mature T cells and by a subpopulation of B cells, mainly memory B cells. In mouse, CD27 has been found on nearly all thymocytes excluding a population of CD46-CD8- precursors. CD27 binds to CD70 and, through this interaction, plays an important role in T cell-B cell interaction. It has been reported that triggering CD27 plays an important role in the maturation of CD4+ and CD8+ effector cells. LG.8F10 cross-reacts with human and rat CD27.When the monoclonal antibody LG.3A10 is crosslinked on purified T cells, proliferation is increased. In the absence of crosslinking, the antibody inhibits CD27-CD70 interaction.
• Synonyms: S152; S152. LPFS2; T14; TNFRSF7; Tp55

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction