Cd3e Mouse Monoclonal Antibody [Clone ID: eBioG4.18 (G4.18)]

CAT#: TA320271

Mouse Anti-Rat CD3 Purified (100 ug)

Product Images

Staining of rat splenocytes with 0.25 ug of Mouse IgG3 Isotype Control Purified (open histogram) or 0.25 ug of Anti-Rat CD3 Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE. Cells in the lymphocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: eBioG4.18 (G4.18)
• Applications: FC
• Recommended Dilution: Flow, IHC, IP, WB
• Reactivities: Rat
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD3e molecule
• Database Link:
  NP_001101610
  Entrez Gene 315609 Rat
• Background: The eBioG4.18 monoclonal antibody recognizes the rat CD3 protein. CD3 is a critical component of the T-cell receptor (TCR) and is a marker of the T-cell lineage. CD3 is a complex of several subunits and, upon binding of a TCR ligand, participates in transduction of signals from the TCR to the nucleus which results in a variety of cellular responses including transcription of IL-2 and clonal expansion. in vitro, immobilized G4.18 monoclonal antibody has been demonstrated to activate T cells, while soluble G4.18 inhibited allogeneic mixed-lymphocyte proliferative responses and cell-mediated cytotoxicity to allogeneic target cells. in vivo, G4.18 was demonstrated to induce long-term specific tolerance to an organ allograft.
• Synonyms: CD3-epsilon; FLJ18683; T3E; TCRE