CD3E Mouse Monoclonal Antibody [Clone ID: HIT3a]

CAT#: TA320272

Mouse Anti-Human CD3 Purified (100 ug)

Product Images

Staining of normal human peripheral blood cells with Mouse IgG2a K Isotype Control Purified (open histogram) or Anti-Human CD3 Purified (filled histogram) followed by Anti-Mouse IgG FITC. Cells in the lymphocyte gate were used for analysis.

Specifications

Product Data

• Clone Name: HIT3a
• Applications: FC
• Recommended Dilution: Flow
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD3e molecule
• Database Link:
  NP_000724
  Entrez Gene 916 Human
  UniProt ID P07766
• Background: The HIT3a monoclonal antibody reacts with human CD3e, a 20 kDa subunit of the TCR complex. Along with the other CD3 subunits gamma and delta, the epsilon chain is required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Crosslinking of TCR with HIT3a initiates an intracellular biochemical pathway resulting in cellular activation and proliferation.
• Synonyms: IMD18; T3E; TCRE

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway