Cd40 Hamster Monoclonal Antibody [Clone ID: HM40-3]

CAT#: TA320279

Hamster Anti-Mouse/Rat CD40 Purified (100 ug)

Product Images

Staining of BALB/c splenocytes with 0.5 ug Armenian Hamster IgG Isotype Control Purified (open histogram) or 0.5 ug Anti-Mouse/Rat CD40 Purified (filled histogram) followed by Anti-Armenian Hamster IgG FITC. Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: HM40-3
• Applications: FC
• Recommended Dilution: Flow, IHC, Functional Assay
• Reactivities: Mouse, Rat
• Host: Hamster
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD40 antigen
• Database Link:
  NP_035741
  Entrez Gene 171369 RatEntrez Gene 21939 Mouse
  UniProt ID P27512
• Background: The HM40-3 monoclonal antibody reacts with mouse and rat CD40, a 45-50 kDa type I transmembrane glycoprotein. CD40 is a member of the TNFR family and is expressed by mouse B lymphocytes, follicular dendritic cells, thymic epithelium, and a subset of peripheral T cells. CD40 regulates B cell development/maturation by inducing Ig isotype switching and in combination with other signals such as IL-4, protects B cells from surface Ig-induced apoptosis and promotes proliferation. Interaction of CD40 with CD154 (gp39), its ligand on T cells, is important in T-B cell crosstalk and plays a role in costimulation and immune regulation.
• Synonyms: Bp50; CDW40; MGC9013; p50; TNFRSF5