Cd8a Rat Monoclonal Antibody [Clone ID: 53-6.7]

CAT#: TA320299

Rat Anti-Mouse CD8a Purified (100 ug)

Product Images

Staining of C57Bl/6 splenocytes with 0.125 ug of Rat IgG2a Isotype Control Purified (open histogram) or 0.125 ug of Anti-Mouse CD8 Purified (filled histogram) followed by Anti-Rat IgG FITC. Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: 53-6.7
• Applications: FC
• Recommended Dilution: Flow, IHC, IP
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: CD8 antigen, alpha chain
• Database Link:
  NP_033987
  Entrez Gene 12525 Mouse
  UniProt ID P01731
• Background: The 53-6.7 monoclonal antibody reacts with the mouse CD8a molecule. CD8a is an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha beta) or as a homodimer (CD8 alpha alpha). A majority of thymocytes and a subpopulation of mature alpha beta TCR T cells express CD8 alpha beta while gamma delta TCR T cells, a subpopulation of intestinal intraepithelial lymphocytes (IELs) and dendritic cells express CD8 alpha alpha. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells.
• Synonyms: CD8; Leu2; MAL; OTTHUMP00000203721; p32