Ceacam1 Mouse Monoclonal Antibody [Clone ID: CC1]

CAT#: TA320309

Mouse Anti-Mouse CD66a (CEACAM1) Purified (25 ug)

Specifications

Product Data

• Clone Name: CC1
• Recommended Dilution: Flow, IHC, Functional Assay
• Reactivities: Mouse
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: carcinoembryonic antigen-related cell adhesion molecule 1
• Database Link:
  NP_036056
  Entrez Gene 26365 Mouse
  UniProt ID P31809
• Background: The monoclonal antibody CC1 recognizes CD66a, also known as carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), biliary glycoprotein, and BPG. Expression of CD66a is found on brush borders, epithelial, and endothelial cells. In hematopoietic cells expression is found abundantly on B cells, as well as some NKs, monocytes, DCs, and granulocytes. Although low levels of mRNA have been identified in T cells in humans, resting mouse T lymphocytes are not reported to express CD66a, as confirmed by lack of staining with CC1 antibody. In humans, expression levels of CD66a have been used to identify malignancies. CD66a plays a key role as a regulator of BCR activation of B lymphocytes. An alternate allele, CEACAM1b, is expressed in SJL mice; therefore, CC1 does not stain SJL tissue. The monoclonal CC1 has been shown to block viral infection and also enhance B cell proliferation when combined with IgM crosslinking.
• Synonyms: BGP; BGP-1; BGP1; BGPI; CD66a