CXCR1 Mouse Monoclonal Antibody [Clone ID: eBio8F1-1-4 (8F1-1-4)]

CAT#: TA320317

Mouse Anti-Human CD181 (CXCR1) Purified (100 ug)


USD 195.00

5 Days*

Size
    • 100 ug

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Specifications

Product Data
Clone Name eBio8F1-1-4 (8F1-1-4)
Applications FC
Recommended Dilution Flow, IHC
Reactivities Human
Host Mouse
Clonality Monoclonal
Formulation Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Concentration lot specific
Purification Affinity purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name C-X-C motif chemokine receptor 1
Background The eBio8F1-1-4 monoclonal antibody reacts with human CD181 (CXCR1, IL-8Rα). CD181 is a 67-70 kDa member of the 7-transmembrane spanning G-protein coupled receptor (GPCR) family. CD181 is expressed as a homodimer, or a heterodimer with CD182 (CXCR2, IL-8Rβ) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-α, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
Synonyms C-C; C-C-CKR-1; CD128; CD181; CDw128a; CKR-1; CMKAR1; IL8R1; IL8RA; IL8RBA
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.