Dll1 Hamster Monoclonal Antibody [Clone ID: HMD1-5]

CAT#: TA320321

Hamster Anti-Mouse DLL1 (delta-like 1) Purified (100 ug)

Product Images

Staining of Delta-like 1-transfected CHO cells with 0.25 ug of Armenian Hamster IgG Isotype Control Purified (blue histogram) or 0.25 ug of Anti-Mouse DLL1 (delta-like 1) Purified (purple histogram). Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: HMD1-5
• Applications: FC
• Recommended Dilution: Flow, IHC
• Reactivities: Mouse
• Host: Hamster
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: delta-like 1 (Drosophila)
• Database Link:
  NP_031891
  Entrez Gene 13388 Mouse
  UniProt ID Q61483
• Background: The HMD1-5 monoclonal antibody reacts with mouse Delta-like 1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Delta-like 1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by γ-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Delta-like 1 is expressed by thymic stromal cells, as well as on macrophages, dendritic cells, and stromal cells in the spleen. This protein is also expressed in nonhematopoietic tissues such as the lung and brain. Delta-like 1 has been linked to B cell development and differentiation, especially marginal zone and plasma cells, regulation of splenic dendritic cells, and leukemogenesis.
• Synonyms: Delta; DELTA1; DL1; H-Delta-1