VEGF Receptor 1 (FLT1) Rat Monoclonal Antibody [Clone ID: 7A6]

CAT#: TA320332

Rat Anti-Human VEGF Receptor 1 (Flt1) Purified (25 ug)

Product Images

Immunoblot analysis of non-boiled NP-40 lysates from Human Umbilical Vein Endothelial Cells (HUVEC) run on SDS-PAGE under non-reducing conditions. The membrane was probed with 2 ug/ml of Anti-Human VEGF Receptor 1 (Flt1) Purified followed by Anti-Rat IgG HRP.

Specifications

Product Data

• Clone Name: 7A6
• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: fms related tyrosine kinase 1
• Database Link:
  NP_002010
  Entrez Gene 2321 Human
  UniProt ID P17948
• Background: This 7A6 monoclonal antibody recognizes human VEGFR1 (vascular endothelial growth factor receptor 1, fms-like tyrosine kinase 1, FLT1). It is directed against the extracellular domain and can recognize both membrane-bound and soluble forms of VEGFR1, with approximate molecular weights of 180 kDa and 90 kDa, respectively. Mice lacking expression of VEGFR1 have disorganized vasculature and die in utero, however angiogenesis does not require the tyrosine kinase activity of VEGFR1 as expression of a membrane-bound form lacking the tyrosine kinase domain allows normal development. Although fertile and viable, mice lacking the tyrosine kinase domain of VEGFR1 do have a defect in the migration of macrophages. The soluble form of VEGFR1 can be detected in the serum of normal patients, and elevated levels of soluble VEGFR1 in pregnant women is associated with preeclampsia. Several tumor cell lines have been reported to express membrane-bound VEGFR1, including malignancies of hematopoietic origin.
• Synonyms: FLT; FLT-1; VEGFR-1; VEGFR1

Reference Data

• Protein Families: Druggable Genome, Protein Kinase, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Focal adhesion