Icos Rat Monoclonal Antibody [Clone ID: 7E.17G9]

CAT#: TA320352

Rat Anti-Mouse CD278 (ICOS) Purified (50 ug)

Product Images

Staining of unstimulated (left) and 3 day ConA activated (right) BALB/c splenocytes with 0.06 ug of Rat IgG2b Isotype Control Purified (open histogram) or 0.06 ug of Anti-Mouse CD278 (ICOS) Purified (filled histogram) followed by Anti-Rat IgG Biotin and Streptavidin PE. Total viable cells were used for analysis.

Specifications

Product Data

• Clone Name: 7E.17G9
• Applications: FC
• Recommended Dilution: Flow
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: inducible T cell co-stimulator
• Database Link:
  NP_059508
  Entrez Gene 54167 Mouse
  UniProt ID Q9WVS0
• Background: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells.
• Synonyms: AILIM; CD278; MGC39850