IL15RA Mouse Monoclonal Antibody [Clone ID: eBioJM7A4]

CAT#: TA320359

Mouse Anti-Human IL-15 Receptor Purified (100 ug)

Product Images

Staining of adherent human PBMCs stimulated with LPS and IFN gamma for 24 hours with 0.25 ug of Mouse IgG2b K Isotype Control Purified (open histogram) or 0.25 ug of Anti-Human IL-15 Receptor Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE. Cells in the large scatter population were used for analysis.

Specifications

Product Data

• Clone Name: eBioJM7A4
• Applications: FC
• Recommended Dilution: Flow, IP, WB
• Reactivities: Human
• Host: Mouse
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 15 receptor subunit alpha
• Database Link:
  NP_751950
  Entrez Gene 3601 Human
  UniProt ID Q13261
• Background: The eBioJM7A4 monoclonal antibody reacts with the IL-15 receptor alpha chain (IL-15Rα). IL-15 and IL-2 are cytokines with overlapping, but distinct, biologic effects. Their receptors share 2 subunits, the IL2R-β and -γ chains, which are essential for signal transduction. The IL-15R-α receptor is structurally related to IL-2R-α. However, the IL-15Rα alone binds IL-15 with a 1,000-fold higher affinity than that seen with IL-2R-α and IL-2. In the human, 3 differentially spliced human IL15R-α variants that are all capable of high affinity binding of IL-15 have been isolated. The cytoplasmic domain of IL15R-α, like that of IL2R-α, is dispensable for mitogenic signaling, suggesting that the primary role of the alpha chains is to confer high affinity binding. At high concentrations, IL-15, like IL-2, is able to signal through a complex of IL2R-β and IL2R-γ in the absence of the alpha subunit.
• Synonyms: CD215

Reference Data

• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway