Itgb1 Rat Monoclonal Antibody [Clone ID: KMI6]

CAT#: TA320393

Rat Anti-Mouse CD29 Purified (100 ug)

Product Images

Balb/c spleen cell lysate (3x10e5 cells/lane) was resolved by SDS-PAGE under non-reducing conditions, immunoblotted with 2 ug/mL Anti-Mouse CD29 Purified and revealed with Anti-Rat IgG HRP.

Specifications

Product Data

• Clone Name: KMI6
• Applications: WB
• Recommended Dilution: Flow, IHC, Functional Assay, IP, WB
• Reactivities: Mouse
• Host: Rat
• Clonality: Monoclonal
• Formulation: Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
• Concentration: lot specific
• Purification: Affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: integrin beta 1 (fibronectin receptor beta)
• Database Link:
  NP_034708
  Entrez Gene 16412 Mouse
  UniProt ID P09055
• Background: The KMI6 monoclonal antibody reacts with mouse CD29 (integrin β1), a 120-130 kDa member of the β integrin family expressed by leukocytes, endothelial, smooth muscle and epithelial cells. CD29 binds non-covalently with the α integrins CD49a-f, to form the VLA-1 through VLA-6 complexes, respectively, and also with CD51. These αβ integrin heterodimers are capable of mediating a variety of cellular responses including adhesion, trafficking, proliferaton and differentiation. All of the integrins which include CD29 bind to extracellular matrix proteins including collagen, laminin, fibronectin and vitronectin, whereas some CD29-containing integrins also interact with cellular receptors including VCAM-1 and MadCAM-1. The KMI6 antibody has been shown to be an activating antibody for β1 integrins, enhancing lymphocyte binding to fibronectin.
• Synonyms: CD29; FNRB; GPIIA; MDF2; MSK12; VLA-BETA; VLAB